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Clinical Papers

Intense pulsed light source for the treatment of dye laser resistant port wine stains


PubMed Reference: Bjerring P, et al. J Cosmet Laser Ther. 2003 Apr;5:7-13.

Study Details: 

  • 15 subjects (9 males, 6 females; mean age 31.2±11.5 years; skin types I-II) with PWS on the face, neck, arm or trunk that were previously found to be resistant to multiple (up to 15) PDL treatments
  • 4 IPL treatments at 2-month intervals with 555-950 nm (VL applicator): spot size of 10x48 mm, fluence 13-22 J/cm2 to reach purpura level, pulse duration 8-30 ms (based on PWS color)
  • Blinded evaluation of digital photography by 1 dermatologist, based on a 5-point improvement scale (0-24%, 25-49%, 50-74%, 75-100%)

Study Results: 

  • 44.2%±39.2% mean clearance for all subjects by blinded evaluation
  • 7 patients (46.7%) responded to treatment (>25% clearance)
  • 85.7% of responders had >75% clearance (remaining 14.3% of subjects had between 50-74%clearance)
  • All non-responders (<25% clearance) had PWS located in the central face
  • Immediate side effects included edema lasting 2 hours after treatment up to 5 days and crusting up to 10 days
  • Subjects should be advised that IPL treatment on hair-bearing skin may result in permanent hair reduction