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Clinical Papers

Skin Rejuvenation Using Intense Pulsed Light A Randomized Controlled Split Face Trial with Blinded Response Evaluation


PubMed Reference: Hedelund L, et al. Arch Dermatol. 2006 Aug;142(8):985-90.

Study Details: 

  • 32 females with mean age 47 years, Fitzpatrick Skin Types I-III and class I or II rhytids
  • Randomized split-face design: no treatment on one side vs. 3 IPL treatments (530-750 nm, PR applicator) at 1-month intervals on the opposite side of the face: 10x48-mm spot size; 2.5-ms double pulses with 10-ms delay; fluence 7.5-8.5 J/cm2
  • Blinded clinical evaluation, by an independent physician, of skin texture, rhytids, telangiectasia and irregular pigmentation, based on 4-point scale: no difference, mild difference, moderate difference or marked difference

Study Results: 

  • Statistically significant improvement (p<0.006) in skin texture on treated side at 1, 3 and 9 months
  • Statistically significant improvement (p<0.001) of telangiectasias on treated side at 1 and 9 months
  • Statistically significant improvement (p<0.03) of irregular pigmentation on treated side at 1 and 9 months
  • All patients showed darkening of lentigines and freckles during the 1st week after treatment
  • 1 case of crusting on the chin that developed into an atrophic scar
  • No purpura or pigmentary changes
  • Long-term improvement of skin texture, telangiectasias and irregular pigmentation