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Clinical Papers

Picosecond 532-nm neodymium-doped yttrium aluminum garnet laser-a promising modality for the management of verrucous epidermal nevi


PubMed Reference: Levi A, Amitai DB, Mimouni D, et al. Lasers Med Sci. 2018 Jan. 

Study Details: 

  • 6 subjects (3 males, 3 females) with skin phototypes I-II with verrucous epidermal nevus (VEN) on the body or face
  • 4 of the 6 subjects had been unsuccessfully treated with laser and/or cryotherapy
  • 2-6 PicoWay Zoom 532nm treatments, with spot size of 3 mm and fluence of 1.8 J/cm2 (up to 3 passes) at 8 to 10-week intervals
  • 2 blinded dermatologists assessed clinical images at 4 months after the final treatment, using a 5-point scale of 0 (exacerbation) to 4 (76-100% improvement)

Study Results: 

  • 100% of subjects demonstrated significant improvement (mean ±3.7 ± 0.45) on the 0-4 scale
  • Treatments were well tolerated with minimal complications
  • 100% subject satisfaction
  • No residual adverse effects or scarring