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Clinical Papers

Photorejuvenation by Intense Pulsed Light with Objective Measurement of Skin Color in Japanese Patients


PubMed Reference: Negishi K, et al. Dermatol Surg. 2006 Nov;32:1380-7.

Study Details: 

  • 25 Japanese women with mean age 50±9 years (range 31-68), Fitzpatrick Skin Types III-IV and mild (n=16), moderate (n=6) or severe (n=3) photodamage
  • 3 full-face IPL treatments 530-750 nm, PR applicator) at 3-4 weeks intervals 10 x 48-mm spot size 2.5-ms double pulses with 10-ms delay; fluence 5.5-7.0 J/cm2 (1st treatment); 5.5-7.0 J/cm2 (2nd treatment) and 6.5-8.0 J/cm2 (3rd treatment)
  • Blinded photographic evaluation by 2 independent physicians, based on 5-point scale: A= 75-100%, B= 50-74%, C=25-49%, D=1-24% and E=no change
  • Spectrophotometric evaluation of skin tone

Study Results: 

  • 96% of subjects showed Grade B or > (50-100%) improvement of skin texture
  • 64% of subjects showed Grade B or > (50-100%) improvement of pigmentation
  • High patient satisfaction (all patients reported satisfied to extreme satisfaction)
  • Statistically significant increase (p=0.001) in skin “lightness” (L* value)
  • 1 case of exacerbation of very subtle epidermal melasma at 3 months
  • No blistering, hypopigmentation or skin atrophy